Dave Weisberger, co-founder of CoinRoutes, stated that the most significant remaining barrier to institutional Bitcoin adoption is not exchange-traded funds or corporate treasury strategies, but rather the treatment of Bitcoin as collateral. He explained that banks currently face a haircut close to 100% when using Bitcoin as collateral, effectively neutralizing its utility in lending and balance sheet management. Weisberger described this regulatory hurdle as the "final boss" for institutional integration.

According to Weisberger, once Bitcoin is treated like other assets based on volatility and liquidity metrics, it will fundamentally change operations for lenders and companies such as Strategy Inc (formerly MicroStrategy). He noted that while the Basel committee and various rulemakers have described the removal of this haircut as inevitable, the change has not yet occurred. The discussion also touched on tokenization, Hyperliquid, and broader market structure dynamics involving perpetual swaps and segregated accounts.